Since L-arginine is both Dose-Dependent and Timing-Dependent, the benefits derived from taking L-ArginineM ² are based on the amount taken (Dose-Dependent) and the time it is taken (Timing-Dependent).

Therefore, there are four (4) different Protocols for achieving dose-related and time-related benefits from L-ArginineM ².

Each of the four (4) Protocols is attained by following a specific Regimen as follows:

The Daytime Protocol is appropriate for the following claims:

Amount:
One 12.5 gram packet of L-ArginineM²contains 5 grams (5,000 mg) of Elemental L-arginine, the therapeutic dose required for daytime use.

Use one 12.5 gram packet of L-ArginineM² mixed with 4-8 ounces of water.

Do not use flavored or enhanced water. Do not use juice. Use only plain, tap, or bottled water.

Timing: Take (1) 12.5 gram packet (mixed in water) in-between meals.

Do not take with meals or within ½ hour of meals or snacks. May be taken 1-3 times per day as desired or as directed by a physician.

Contraindications: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-citrulline or any other amino acid or protein.

The Night-Time Protocol is strictly for use by persons over age 23. Do not use any L-arginine product at bedtime or night-time in persons who are under age 23, as they are still producing growth hormone (GH), and growth factors. Using L-ArginineM² , or any other L-arginine product to increase height will not work, as total height is genetically controlled and cannot be altered.

For persons over age 23, the Night-Time Protocol is appropriate for the following claims:

Amount: Two 12.5 gram packets of L-ArginineM² contain 10 grams (10,000 mg) of Elemental L-arginine, the therapeutic dose required for Night-Time use. 25 total grams of L-ArginineM² contain 10 grams of pure L-arginine.

Use two (2) 12.5 gram packets of L-ArginineM² mixed with 8 ounces of water or any preferred amount of water. Some people wish to use a smaller amount of water at bedtime to avoid night-time urination. The amount of water used is not important, as long as the 2 packets are thoroughly mixed . Do not pre-mix L-ArginineM² with water and let it sit for more than 10 minutes.

Do not use flavored or enhanced water. Do not use juice. Use only plain, tap, or bottled water.

Timing: Take 2 packets (mixed in water)30minutesprior to sleep.
Example: Dinner 8 PM. Take L-ArginineM² 11 PM. Go to sleep at 11:30 PM.

L-ArginineM² Night-Time Regimen must be taken on an empty stomach. You cannot eat for 2-3 hours prior to taking the Night-Time dose, or the product will not work (accessing the BBB and Delta sleep cycle is mandatory).

Do not take within 2-3 hours of meals or snacks or drinks other than water. May be taken only one (1) time per day at bedtime.

Contraindications: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-citrulline or any other amino acid or protein.

The Preferential Fat-Burning Protocol is primarily for persons who wish to use L-ArginineM² as an adjunct to reducing excess adipose body fat and is appropriate for the following claims:

Mechanism for Preferential Fat-Burning

When L-ArginineM² is used as a drink prior to and during exercise, it triggers a relative shift in substrate utilization from carbohydrate to FAT.

The biochemical mechanism by which L-ArginineM² preferentially triggers Adipose Tissue Fat-Burning (ATFB)is aresultoftheuniquecombinationofTrutina Dulcem bonded to the Elemental L-arginine molecules in a low glycemic matrix.

No other Arginine product worldwide can produce Preferential Fat Burning.

L-ArginineM² taken as a drink prior to and during exercise reduces the weight of abdominal (retroperitoneal) and epididynal adipose tissue fat tissues (45 and 25% respectively).

L-ArginineM² increases adipose tissue fat expression of genes aligned with glucose oxidation and fatty acid oxidation by 120 % to 800 % via Heme Oxygenase-3, PPARC-1, NOs- 1, and AMP-A Protein Kinase.

An ideal exercise for this mechanism is using a treadmill @ 70% VO2max. Alternatively, fast walking or light jogging will also trigger the appropriate VO2max.

Amount: One 12.5 gram packet of L-ArginineM² contains 5 grams (5,000 mg) of Elemental L-arginine, the therapeutic dose required for the Fat-Burning Regimen.

Use one (1) 12.5 gram packet of L-ArginineM² mixed with 8-12 ounces of water.

Do not use flavored or enhanced water. Do not use juice. Use only plain, tap, or bottled water.

Timing: Take one (1) 12.5 gram packet L-ArginineM² and mix in 8-12 ounces of water. You may place 1 packet in your sports bottle, add water, and shake to dissolve. Drink the entire contents prior to and during exercise.

Do not take with meals or within ½ hour of meals or snacks. Do not use any sports drink within 2 hours of using the Fat-Burning Regimen - water only.

May be taken 1-2 times per day prior to exercise.

Contraindications: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-citrulline or any other amino acid or protein.

The Protocol for Athletes is designed for the professional, competing, world-class, and/or serious athlete. Persons under age 23 may not use this regimen.

This regimen is designed to increase muscle mass and muscle mitochondria, increase strength, reduce adipose tissue body fat, and to shorten recuperation time.
For persons over age 23, the Athlete’s Regimen is appropriate for the Following Claims:

Serious Results for Serious Athletes

Directions for Athletes taking L-ArginineM² are very precise, and must be followed to the letter in order to obtain maximum benefits.

After two decades of working with hundreds of World-Class athletes, our advanced L-arginine research and protocols have been finely-tuned, and are considered the most successful in the entire sports industry.

Reaching Human Maximum Performance in sports requires that an athlete maximize his/ her genetic and individual physical potential. This requires working one-on-one with:

GAINING "THE EDGE"

Without an "Edge" the athlete is doomed to mediocrity. The "Edge" is gained by going beyond the barriers required of normal persons, and achieving Human Maximum Performance. All nine (9) of the parameters directly tied to athletic ability must be addressed in order to reach Human Maximum Performance. Trial and error do not work in the highly competitive field of sports.

The utilization of L-ArginineM² in a Human Maximum Sports Performance Program addresses numbers 5 and 9 of the parameters specifically:

Performance Hormone Levels
An athlete’s ability to perform is largely dependent on his/her hormone levels. The most important sports performance hormones (in males and females) are testosterone and growth hormone.

Athletes with genetically low testosterone or growth hormone (GH) levels will not be able to compete at a high level. Sub-optimal levels of performance hormones result in ultimate failure in the professional and competitive sports arena.

In humans, the primary function of performance hormones is to provide:

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Many athletes turn to illegal steroids, and synthetic testosterone and GH to increase their performance abilities. These drugs are illegal and dangerous, and reduce lifespan. They are also unnecessary. There are legal and safe methods for naturally and legally increasing performance hormones in humans.

Normal humans produce very high amounts of performance hormones, such as testosterone and GH, during ages 15-18. After age 23, production of these hormones decrease, and continue to descend as age progresses. At age 30, the decline begins to aff ect sports performance.

Though the brain (via the hypothalamus/pituitary axis) "turns off" its production of performance hormones as age progresses (beginning at age 23), this axis can be re-instated in a natural and legal methodology in humans.

The brain is completely able and capable of reinstating the same performance hormones as those found in a teenager. It requires precise dosing and timing, and the ability of L-arginine to cross the Blood-Brain-Barrier (BBB). If L-arginine does not cross the BBB, there is no reinstating or release of performance hormones.

Therefore, athletes cannot take L-arginine in a form that is incapable of crossing the Blood-Brain-Barrier (BBB).

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Amount For Athletes

In order to elicit any performance hormone response from the brain, including growth hormone and testosterone, a minimum of 10,000 mg (10 grams) of Elemental L-arginine is required. Anabolic, anti-aging and sports performance benefits only occurs when 10 grams of pure elemental L-arginine is ingested in a low glycemic format with no competing proteins, amino acids, maltodextrins, or sugars.

The appropriate dose for most athletes is 2 packets of L-ArginineM².

10 grams of L-arginine = 2 individual packets of
L-ArginineM²

2 packets of L-ArginineM² contain 10 grams (10,000 mg) of Elemental L-arginine.

3 packets contain 15 grams (15,000 mg) of Elemental
L-arginine.

2-3 packets are the therapeutic doses required for the athlete, depending on the size of the individual.

When mixing L-ArginineM², do not use flavored or enhanced water. Do not use juice. Use only plain, tap, or bottled water. Biochemically speaking, de-ionized water is the best form of water available (not distilled or spring water).

Selecting Appropriate Serving Size: Athletes can decide how many servings to take depending on personal goals and overall size. Start by taking 1 serving the first night and then increase to 2-3 servings, if desired, over a period of a few days.

See Contraindications for exemptions.

Athletes Timing:

Take L-ArginineM² 30 minutes prior to sleep on a totally empty stomach. A totally empty stomach means nothing taken but water 2-3 hours prior to taking L-ArginineM². You must take L-ArginineM² thirty (30) minutes prior to sleep because L-arginine must cross the Blood Brain Barrier (BBB) during Delta Sleep.

In athletes, if you have anything in your stomach for two hours prior taking L-ArginineM², it is not going to work, and will be a waste of time, money and effort.

Athletes only produce significant amounts of growth hormone (GH) two times in a 24-hour period:

Therefore, athletes can take L-ArginineM² (at GH doses/2+ individual packets) twice per day, while the non-athlete should not.

Timing For 1.) Sleep Cycle

Take 2-3 packets L-ArginineM² and mix in ½ - 1 cup water. Use enough water for the powder to go into solution. If the water is cold, it may take a minute for solubility.

Take at bedtime (on a totally empty stomach) 30 minutes prior to sleep. Do not pre-mix the product and let it sit for more than 10-15 minutes.

Do not take with meals or within ½ hour of meals or snacks. Do not use any sports drink within 2 hours of using the Athletes Regimen – water only. Ingesting food, amino acids, or proteins with or near this product is not in any way harmful, it simply will negate the benefits.

Timing For 2.) Intense Exercise

Athletes may take an optional 1-2 servings 30 minutes prior to intense exercise on an empty stomach. Intenseexerciseis definedas liftingweightsor resistance exercise (not aerobic exercise). If taking L-ArginineM² 30 minutes prior to sleep is problematic, the athlete may instead utilize Timing # 2 (Intense Exercise). In general, athletes should not eat close to bedtime, as it interferes with the body’s natural cycles and production of anabolic muscle building.

Athletes Suggestions:

If an athlete is not accustomed to taking large doses of L-arginine, a slow-start program may be acceptable. In persons not accustomed to taking large doses of L-arginine, soft stools or mild diarrhea may occur. This is a normal reaction to high-dose L-arginine. In said cases, reduce the amount taken until normal stools return.

Start off the first night with one packet which is 5 grams of L-arginine. For 2-3 nights just take one packet. Then increase to 2 packets, which is 10 grams of elemental L-arginine. Take 10 grams per night at bed time for about 3 weeks to a month. The body should then be accustomed to large doses of L-arginine.

Increased Doses: Directions for male athletes electing to use more than 10 grams of L-arginine at bedtime:

After working up to10 grams (without diarrhea), athletes may elect to start taking 15 grams (3 packets) per night at bedtime.

Female athletes should stay at 10 grams.

Contraindications: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-citrulline or any other amino acid or protein. Non-athletes should not take more than 10 grams of L-arginine at one time.

"Legal Claims" herein stated (1-15) are solely related to the L-ArginineM² Patent, as awarded to Dr. Ann de Wees Allen, the exclusive inventor and Patent-holder of L-ArginineM².

Each of the fifteen (15) claims for L-ArginineM² have been submitted and analyzed by FDA and FTC regulatory attorneys and are allowed under the Dietary Supplement Health and Education Act of 1994.

Said claims have been determined to meet the legal requirements of "Dietary Supplement Structure/Function" claims per government regulations, as related to Dr. Allen’s Patent for L-Arginine, and upon review of the Patent’s documentary evidence and clinical substantiation spanning a two-decade period of more than 25 years, including broad use of safety in humans.

The following claims are unique to the L-ArginineM² Patent and evidential documents submitted since 1983, and may not be used for any other product or patent, under penalty of law.

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